Actions for Biconformal Matter

We extend 2n-dim biconformal gauge theory by including Lorentz-scalar matter fields of arbitrary conformal weight. For a massless scalar field of conformal weight zero in a torsion-free biconformal geometry, the solution is determined by the Einstein equation on an n-dim submanifold, with the stress-energy tensor of the scalar field as source. The matter field satisfies the n-dim Klein-Gordon equation.Comment: 5 page

Multi-qubit Randomized Benchmarking Using Few Samples

Randomized benchmarking (RB) is an efficient and robust method to characterize gate errors in quantum circuits. Averaging over random sequences of gates leads to estimates of gate errors in terms of the average fidelity. These estimates are isolated from the state preparation and measurement errors that plague other methods like channel tomography and direct fidelity estimation. A decisive factor in the feasibility of randomized benchmarking is the number of sampled sequences required to obtain rigorous confidence intervals. Previous bounds were either prohibitively loose or required the number of sampled sequences to scale exponentially with the number of qubits in order to obtain a fixed confidence interval at a fixed error rate. Here we show that, with a small adaptation to the randomized benchmarking procedure, the number of sampled sequences required for a fixed confidence interval is dramatically smaller than could previously be justified. In particular, we show that the number of sampled sequences required is essentially independent of the number of qubits and scales favorably with the average error rate of the system under investigation. We also show that the number of samples required for long sequence lengths can be made substantially smaller than previous rigorous results (even for single qubits) as long as the noise process under investigation is not unitary. Our results bring rigorous randomized benchmarking on systems with many qubits into the realm of experimental feasibility.Comment: v3: Added discussion of the impact of variance heteroskedasticity on the RB fitting procedure. Close to published versio

Diaphragm myoclonus followed by generalised atonia in a patient with trisomy 4p: unusual semiology in an unusual condition.

In this report, we describe a female patient with trisomy 4p, a rare genetic condition, with unusual seizure semiology. The patient is one of the oldest reported survivors with this condition. This semiology was noted while she was being monitored by inpatient video telemetry. We observed a series of myoclonic shoulder jerks, followed by hiccup-like episodes, and finally an atonic head drop. Corresponding ictal EEG showed semi-rhythmic high-amplitude slow waves with spikes superimposed over the frontotemporal areas. This semiology was confirmed as habitual by her parents. Subsequent hiccup-like episodes had no EEG correlate, and the head drop was again associated with semi-rhythmic high-amplitude slow waves and superimposed spikes, more prominent over the right hemisphere. In addition, we review the several cases in which hiccups have been associated with seizures and how this may relate to the neural pathways involved in the pathophysiology of hiccups. We believe the ictal hiccup-like episodes followed by atonia to be a seizure semiology that has not previously been documented

Long-distance navigation in the wandering desert spider Leucorchestris arenicola: can the slope of the dune surface provide a compass cue?

Males of the nocturnal spider Leucorchestris arenicola (Araneae: Sparassidae) wander long distances over seemingly featureless dune surfaces in the Namib Desert searching for females. The spiders live in burrows to which they return after nearly every such excursion. While the outward path of an excursion may be a meandering search, the return path is often a nearly straight line leading towards the burrow. This navigational behaviour resembles that of path integration known from other arthropods, though on a much larger scale (over tens to hundreds of meters). Theoretically, precise navigation by path integration over long distances requires an external compass in order to adjust for inevitable accumulation of navigational errors. As a first step towards identifying any nocturnal compass cues used by the male spiders, a method for detailed 3-D recordings of the spider's paths was developed. The 3-D reconstructions of the paths revealed details about the processes involved in the spiders' nocturnal way of navigation. Analyses of the reconstructed paths suggest that gravity (slope of the dune surface) is an unlikely parameter used in path integration by the L. arenicola spider

Neck atonia with a focal stimulation-induced seizure arising from the SMA: pathophysiological considerations.

A 28-year-old patient with pharmacoresistant non-lesional right frontal epilepsy underwent extra-operative intracranial EEG recordings and electrical cortical stimulation (ECS) to map eloquent cortex. Right supplementary motor area (SMA) ECS induced a brief seizure with habitual symptoms involving neck tingling followed by asymmetric tonic posturing. An additional feature was neck atonia. During atonia and sensory aura, discharges were seen in the mesial frontal electrodes and precentral gyrus. Besides motor signs, atonia, although rare and not described in the neck muscles, and sensations have been reported with SMA stimulation. The mechanisms underlying neck atonia in seizures arising from the SMA can be explained by supplementary negative motor area (SNMA) - though this was not mapped in electrodes overlying the ictal onset zone in our patient - or primary sensorimotor cortex activation through rapid propagation. Given the broad spectrum of signs elicited by SMA stimulation and rapid spread of seizures arising from the SMA, caution should be taken to not diagnose these as non-epileptic, as had previously occurred in this patient

From Supermassive Black Holes to Dwarf Elliptical Nuclei: a Mass Continuum

Considerable evidence suggests that supermassive black holes reside at the centers of massive galactic bulges. At a lower galactic mass range, many dwarf galaxies contain extremely compact nuclei that structurally resemble massive globular clusters. We show that both these types of central massive objects (CMO's) define a single unbroken relation between CMO mass and the luminosity of their host galaxy spheroid. Equivalently, M_CMO is directly proportional to the host spheroid mass over 4 orders of magnitude. We note that this result has been simultaneously and independently identified by Cote et al. (2006), see also Ferrarese et al. (2006). We therefore suggest that the dE,N nuclei may be the low-mass analogs of supermassive black holes, and that these two types of CMO's may have both developed starting from similar initial formation processes. The overlap mass interval between the two types of CMO's is small, and suggests that for M_CMO > 10^7 M_sun, the formation of a black hole was strongly favored, perhaps because the initial gas infall to the center was too rapid and violent for star formation to occur efficiently.Comment: 4 pages, 2 figures, submitted to ApJ

The role of functional imaging in the tumor patient

Functional imaging studies complement structural magnetic resonance imaging (MRI) in the assessment of patients with brain tumor–associated focal epilepsy. 11C-Methionine (MET) and 18F-fluoro-ethyl-l-tyrosine (FET) are amino acid analogues that highlight metabolically active areas in positron emission tomography (PET). Ictal single photon emission computed tomography (SPECT) can provide information about perilesional areas of seizure onset and early propagation. Functional MRI (fMRI) and diffusion tensor imaging (DTI) allow noninvasive identification of potentially eloquent motor, sensory, and language cortical areas and pathways with an accuracy of 10–15 mm compared to electrocortical stimulation (ECS). Repetitive navigated transcranial magnetic stimulation (TMS) allows even more precise noninvasive delineation of primary motor cortex. Information from functional imaging studies helps in the planning of brain tumor biopsies, resections, and the planning of intracranial video–electroencephalography (EEG) studies

Hypertonicity-induced cation channels rescue cells from staurosporine-elicited apoptosis

Cell shrinkage is one of the earliest events during apoptosis. Cell shrinkage also occurs upon hypertonic stress, and previous work has shown that hypertonicity-induced cation channels (HICCs) underlie a highly efficient mechanism of recovery from cell shrinkage, called the regulatory volume increase (RVI), in many cell types. Here, the effects of HICC activation on staurosporine-induced apoptotic volume decrease (AVD) and apoptosis were studied in HeLa cells by means of electronic cell sizing and whole-cell patch-clamp recording. It was found that hypertonic stress reduces staurosporine-induced AVD and cell death (associated with caspase-3/7 activation and DNA fragmentation), and that this effect was actually due to activation of the HICC. On the other hand, staurosporine was found to significantly reduce osmotic HICC activation. It is concluded that AVD and RVI reflect two fundamentally distinct functional modes in terms of the activity and role of the HICC, in a shrunken cell. Our results also demonstrate, for the first time, the ability of the HICC to rescue cells from the process of programmed cell death

Organizational, Motivational, and Cultural Contexts of Volunteering

This open access book offers a comprehensive view of the phenomenon of volunteer work: it examines motivational factors and questions of corporate organization and the social environment. In particular, this is the first book to present volunteer work in detail as a psychosocial resource and a source of well-being that should not be overused or abused. The book is based on the authors' 15 years of research into volunteer work in Europe. It provides clear instructions on designing volunteer work tasks, and on where boundaries must be respected. The findings include insights into cultural and national differences, and offer practical advice on the organization of volunteer work. This book answers questions like: How do we understand voluntary work? How essential is it that this kind of work remains unpaid and carried out by so-called laypersons with special motives? And what follows from this for the interaction between voluntary work and professionalized, paid employment? The analysis draws on perspectives from wellbeing research, organizational and industrial studies, social work, and related social sciences